Benign cancer in breast

Revista Romana de Anatomie

Phyllodes tumors tend to grow quickly, but they rarely spread outside the breast. Inthe World Health Organization classified the phyllodes tumors into three subtypes benign, borderline and malignantaccording to various clinicopathological characteristics, including the degree of stromal cell atypia and stromal overgrowth, tumor necrosis, the status of mitosis and the tumor margin.

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In this paper we present a case of giant phyllodes tumor of the breast in a young woman, with its clinicopathological particularities and the different treatment options. Acestea au tendinţa de a creş­te ra­pid, diseminând foarte rar în afara sânului.

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ÎnOr­ga­ni­za­­ţia Mondială a Sănătăţii a clasificat tumorile phyllodes în trei sub­ti­puri benigne, borderline şi maligneîn funcţie de di­fe­ri­tele ca­rac­teristici clinicopatologice, incluzând gradul de ati­pie celulară stromală, gradul de necroză tumorală, numărul mi­to­zelor şi prezenţa invaziei marginilor de rezecţie.

În această lu­cra­re prezentăm cazul unei paciente tinere cu tumoră phyllodes, cu particularităţile clinicopatologice pe care le prezintă şi op­ţiunile diferite de tratament.

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The name of the phyllodes tumor comes from the Greek word phullon meaning leaf. Phyllodes tumors are divided into three subtypes benigne, borderline and malignant ,   depending on the degree of the stromal cellular atypia, mitotic activity per 10 high-power fields, degree of stromal overgrowth these three are the maintumor necrosis, and margin appearance. Borderline tumors have the greatest tendency for local recurrence 2,3. All forms of phyllodes tumors have malignant potential and can behave like sarcomas, with metastases to various organs, commonly the lungs, bone and abdominal viscera benign cancer in breast.

The only treatment option for these tumors is the surgical removal. Case report A year-old female presented to our department in December detoxifierea ficatului si rinichilor, with a lump in the left breast that had been gradually increasing for three months.

There have been reported few cases of malignant transformation and many recurrences, therefore it is required an adequate excision of this tumor with clear margins. We present the case of a woman of 47 years old, who was admitted in our Department for a right perimamelonar lump, with uncertain imaging features. A right mammary segmentectomy was performed and the routine histopathological and immunohistochemical examination led to the diagnosis of pleomorphic adenoma of the breast. Pleomorphic adenoma of breast: a radiological and pathological study of a common tumor in an uncommon location. Reporting a rare case of pleomorphic adenoma of the breast.

In the last month before presenting to the hospital, the tumoral mass had ulcerated and started to bleed. A biopsy showed a phyllodes tumor. The patient perfomed total mastectomy without axillary dissection. Figure 1. Large left breast mass on the clinical examination Macroscopic findings A breast tissue measuring 20×18×13 cm in dimensions was resected Figure 2 and Figure 3.

Tumoră phyllodes gigantică

Deep margin displays sole smooth surfaced nodules, cut surface is multinodular and shows variable sized fleshy, soft to firm, off-white to ash colored leafy nodules. Figures 2 and benign cancer in breast.

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The extended area of the epidermis of the covering epidermis, plated with granular tissue with infiltrated polymorphic infiltration lymphocytes, numerous plasmocytes, rare polymorphonuclear neutrophils and eosinophils. The patient was evaluated gynecologically because of uterine changes that showed the presence of multiple uterine fibroids, and at the level of bone system, by bone scintigraphy, that did not show the presence of bone metastases. Postoperatively, the initiation of adjuvant chemotherapy followed by chest irradiation was discussed.

Inthe World Health Organization classified phyllodes tumors into three subtypes benign cancer in breast benign, borderline and malignant —, according to various clinicopathological characteristics, duct papilloma breast treatment the degree of stromal cell atypia and stromal overgrowth, tumor necrosis, the status of mitosis and the tumor margin However, the histologic classification does not always predict the outcome.

Revista Romana de Anatomie

The therapeutic decision is difficult to take due to the lack of predictive factors. Different studies have shown that infiltration of resection margins, elevated mitosis rates, and rapid stromal growth are important prognostic and predictive factors Not all patients with positive margins develop recurrence.

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KI67 is an important prognostic marker. Another tumor prognostic factor was considered the tumoral size, which was found to positively correlate with distant metastasis, and it was also observed that women with distant metastases tended to present with larger tumors Several authors found radiotherapy to reduce the local recurrence rates, but unlike with the usual invasive breast cancers, radiation did not improve the survival in malignant phyllodes Local recurrences still deve­loped in patients who received radiation, but few studies demonstrated that these women had large tumors benign cancer in breast involved benign cancer in breast margins, which rendered them at high risk of recurrence regardless.

Tan and colleagues developed a nomogram to predict recurrence-free survival, based on stromal atypia, mitoses, stromal overgrowth and surgical margins Even though the nomogram was not developed specifically for distant metastasis, it is likely still relevant, since recurrences are more often systemic, rather than isolated local recurrences, in malignant phyllodes.

Conclusions Phyllodes tumors are a heterogeneous tumor group whose prognosis is difficult to define.

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The prognosis depends benign cancer in breast the histological and biological characteristics of the tumors. The only therapeutic method is the surgical treatment at present, and the complete resection with clear surgical margins appears to be the best predictor of a good survival.

Pleomorphic adenoma of the breast | Radu | Archive of Clinical Cases

In case of phyllodes benign and borderline tumors, post-resection follow-up remains the method of choice, although adjuvant chemotherapy and radiotherapy are cancer colon kras in borderline tumors.

Involved margins are associated with distant metastases, and the conventional chemotherapy and radiation treatments do not appear effective.

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Conflict of interests: The authors declare no conflict of interests. Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast.

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Ann Surg Oncol. Breast Cancer, Version 1.

Archive of Clinical Cases

J Natl Compr Canc Netw. A rare case of breast malignant phyllodes tumor with metastases to the kidney: Case report. Medicine Baltimore. Malignant phyllodes tumor of the breast: Treatment and prognosis.

Building upon the strengths of previous editions, this updated volume by Drs. Kirby I. Bland, Edward M.

Breast J. Malignant phyllodes tumours of the breast. A clinical and pathological analysis of 55 cases. Eur J Cancer. Breast Cancer Res Treat.

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Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breast.

Mod Pathol. Altered expression of p53 and its regulated proteins in phyllodes tumours of the breast. J Pathol. Malignant phyllodes tumours of the breast display increased stromal p53 protein expression. The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes. August DA, Kearney T.

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Cystosarcoma phyllodes: mastectomy, lumpectomy, or lumpectomy plus irradiation. Surg Oncol. Utilization of radiotherapy for malignant phyllodes tumors: analysis of the National Cancer Data Base.

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Malignant phyllodes tumor of the breast: treatment and prognosis. Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins.

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