Elizabeth Murchison studies a mysterious and contagious cancer that threatens to wipe out Tasmanian devils. Aggressive cancer spread you should listen Aggressive cancer spread Murchison grew up in Tasmania, the island home of the small, aggressive marsupial known as the Tasmanian devil.
In the mid-'90s, the devils were beset with a terrible new disease -- a contagious facial cancer, spread by biting, that killed the animals just as they reached breeding age. Byhalf the devil population of Australia had contracted the cancer and died.
Analyzing gene and microRNA activity in 25 different facial tumors and in healthy tissue, the team found that cancers from animals across Tasmania were identical, and that the aggressive cancer spread stems from Schwann cells, which normally insulate nerve fibers. Now a Research Fellow in Medical Sciences at King's College, Cambridge, Murchison is using high-throughput DNA sequencing aggressive cancer spread to investigate the genetics and evolution of this disease, one of only three known cancers that spread contagiously.
She says: "This is why cancer is such a difficult disease to treat: It evolves.