Neuroendocrine cancer with carcinoid syndrome.

One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.

Management in Health, Vol 15, No 1 (2011)

They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism. We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile. Material and Methods.

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All papillary lesion of bladder patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly. The fasting glucose insignificantly changed from baseline after 2 years. No new case of diabetes was registered.

NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS

One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive carcinoid symptoms.

The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Neuroendocrine tumors. Endocr Relat Cancer.

METASTATIC CARCINOID TUMOR- ATYPICAL PRESENTATION

DOI: Oberndorfer S. Karzinoide tumoren des dunndarms. Frank Z Pathol.

Psychosocial Aspects of Living with Neuroendocrine Cancer: Patient/Caregiver Panel

Carcinoid Tumors. Bellizzi AM.

Neuroendocrine tumors NETs are found throughout the intestinal tract, the appendix and terminal ileum being the most common locations, and neuroendocrine cancer with carcinoid syndrome classified by site of origin and by degree of differentiation, with well-differentiated lesions representing those tumors formerly referred to as carcinoid tumors. We report the clinical, serological and histological diagnosis of a years-old male patient with congestive heart failure secondary to carcinoid heart disease in the context of liver metastases of an ileum carcinoid tumor. Metastatic carcinoid tumor presenting as right sided heart failure. Int J Endocrinol Metab ;

Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnosis immunohistochemistry. Adv Anat Pathol. Chromogranins A B C: widespread consitituents of secretory vesicles.

NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS | The Medical-Surgical Journal

Ann N Y Acad Sci. Chromogranin A neuron specific enolase carcinoembryonic antigen and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. CO; 8.

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Regul Pept. The poor prognosis factors in Neuroendocrine cancer with carcinoid syndrome neuroendocrine tumor.

Rom J Morphol Embryol. The dedifferentiation of neuroendocrine tumor metastases: myth or reality?

This article provides an overview of the current state of the imaging modalities used for primary tumor visualization, staging and follow-up. Detection of NETs and patient monitoring relies mainly on anatomical imaging such as computed tomography CTmagnetic resonance imaging MRIand ultrasonography US under certain conditions. Molecular imaging techniques in combination with CT or MRI hybrid imaging greatly benefit patient management, including better localization of occult tumors and better staging. Diagnosis of patients with NETs is a complex process and, it is unlikely that any single diagnostic modality to be effective. Thus, NET diagnosis is a process utilizing a variety of methods including blood, urine and tumor tissue samples in combination with anatomical or hybrid imaging for localization, delineation and staging of the disease.

Octreotide for the treatment of hypoglycemia after insulin glargine overdose. J Emerg Med. Biochemical testing for neuroendocrine tumors.

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The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am ;40 1 Well-differentiated neuroendocrine tumor and osteoporosis: incidental finding? Treatment of malignant midgut carcinoid tumours with a long-acting somatostatin analogue octreotide.

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Acta Oncol. Long-term clinical outcome of somatostatin analogues for treatment of pregressive metastatic well-differentiated entero-pancreatic endocrine carcinoma.

Este o boala neoplazica avand ca punct de plecare celulele sistemului endocrin difuz SED. Tumorile carcinoide pot fi localizate oriunde la nivelul tubului digestiv, dar cel mai frecvent le gasim in jurul valvei ileocecale. Pot fi asimptomatice sau pot genera simptome obstructive. Simptomele clinice sunt expresia hipersecretiei hormonale.

Ann Oncol. Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma.

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