Source: Romanian Medical Journal. Inverted papilloma is a rare epithelial benign neoplasm which presents a number of significant therapeutic problems due to a high rate of postoperative recurrence and a significant percentage of malignancy.
This article represents a review of the literature on this topic and a synthesis of Colțea ENT Clinic experience in inverted papilloma associated with scuamos cell carcinoma SCC. Study design. Retrospective, between and 7 years. Out of 36 patients with schneiderian papilloma treated in our clinic, 8 were identified with inverted papilloma associated with SCC.
In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papillomavirus HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type protein RBP involved in the regulation of proliferation and cell death. Materials and method.
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