In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papillomavirus HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.
Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users. Conclusions: The genotyping method was validated according to kit instructions.
To get a general idea on the prevalence of HPV genotypes human papillomavirus (hpv) infection of the larynx has been associated with head and neck cancer in our region we tested a very small number of samples. Ferlay J, Soerjomataram I et al.
Department of Ophthalmology, Grigore T.
Comprehensive control of human papillomavirus infections and related diseases. Venuti A, Paolini F.
Throat Cancer and the Human Papilloma Virus
Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Ursu RG, Danciu M et al. Virol J. Human papillomavirus prevalence in invasive laryngeal cancer in the United States.
Shanesmith R, Allen RA et al. Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cell carcinomas.
HPV genotype distribution in oral and oropharyngeal squamous cell carcinoma using seven in vitro amplification assays. Garnaes E, Kiss K et al. A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, the largest registry-based study to date.
Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions. Westra WH. Heiduschka G, Grah A et al.
Masterson L, Moualed D et al. De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systema-tic review and meta-analysis of current clinical trials.