Cancer de pancreas metastasis,

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ASCAP is a malignant tumor with debatable histogenesis. We report the case of a year-old man, with a history of more than half of a year of right upper quadrant abdominal pain, jaundice, with no anamnestic data of acute or chronic pancreatitis, or substance abuse. Cancer bronhopulmonar stadializare gross examination the tumor was solid, white, poorly circumscribed, located in the head of the pancreas, with 4 cm diameter, and direct extension into ampulla of Vater, common bile duct, and peripancreatic soft tissue.

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Microscopically, the tumor was composed of squamous polygonal cells arranged in small glandular structures, with tightly packed pattern, and mild nuclear pleomorphism, along with small areas with Alcian blue positive intracellular mucin. Therefore, the differential diagnosis between ASCAP and pancreatic collision tumor, metastasis of adenosquamous carcinoma or mucoepidermoid tumor was compulsory.

This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy. In this presentation, we mention the histological types of pancreatic cancer, the importance of systemic therapy for operable cases pre- cancer de pancreas metastasis post-surgeryand of chemotherapy for advanced and metastatic cancer. New therapeutic agents have been introduced, that appear to give new hope for a more efficient treatment.

The immuno-histochemistry assay confirmed ASCAP as the final diagnosis, based on the intense positive reaction for cytokeratin 7 mainly in the glandular structures, whereas cytokeratin 5 and p63 were positive predominantly in the squamous component. The present report aimed to highlight the cancer de pancreas metastasis characteristics of this rare subtype of pancreatic tumors and to point out the difficulty in differentiation between cancer de pancreas metastasis pancreatic and an extra pancreatic biliary tract or ampulla of Vater tumor, due to the extensive tumor growth that interests, in advanced stages, the same anatomical space, given the different prognosis and therapeutic approach of these entities.

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Adenosquamous carcinoma of the pancreas. Digestion ; 72 : Adenosquamous Carcinoma of the Pancreas, Arch Surg. Herxheimer G.

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Uber heterologe Cancroide. Beitr Pathol Anat ; J Surg Res ; cancer de pancreas metastasis : Cancer ; Makiyama K, et al.

J Gastroenterol ; Hsu JT, et al. Clinicopathologic features and outcomes following surgery for pancreatic adenosqua-mous carcinoma, World J Surg Oncol ; 6: Nabae T, et cancer de pancreas metastasis.

Adenosquamous carcinoma of the pancreas: report of two cases, Am J Gastroenterol.

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Okabayashi T, Hanazaki K. Surgical outcome of adenosquamous carcinoma of the pancreas. World J Gastroenterol ; 14 44 :

Popa, UMF Craiova, Institutul de Biologie si Patologie Celulara Nicolae Simionescu, Universitatea Bucurestiorganizații publice de cercetare cu tradiție in domeniul sanatate si bioinformatica, isi propun sa dezvolte colaborarea trans-disciplinara clinica, academica, economica si sa creeze prin sinergie o agenda comuna de CDI. Prin corelarea si coordonarea activitatilor si resurselor, proiectul se concentrează asupra valorificării noii infrastructuri de cercetare a partenerilor. Acestia vor beneficia de cecuri de experiment și mobilități prin utilizarea acestor infrastructuri. Agenda comuna de cercetare cancer de pancreas metastasis va centra in jurul unui studiu sistematic, multi-omic pe un lot semnificativ de pacienti cu cancer de pancreas recrutati din centrele clinice de referinta ale partenerilor.

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