Cancer and genetic changes,

And he was surprised by what he learned. And so it goes in the fledgling genome field. James Lupski of the Baylor College of Medicine in Houston studied his own entire DNA map and sequenced the genomes of family members — including his deceased grandfather — to diagnose the mutation causing his rare genetic nerve disease, called Charcot-Marie-Tooth syndrome. Still, Collins describes this as low-hanging fruit. He says the hard work is only just beginning.

Accepted Apr Copyright © The Authors. This is an open access article under the terms of the Creative Commons Cancer and genetic changes License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.

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Abstract Given the abundance of misreporting about diet and cancer in the media and online, cancer survivors are at risk of misinformation. The aim of this study was to explore cancer survivors' beliefs about diet quality and cancer, the impact on their behaviour and sources of information.

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Interviews were analysed using Thematic Analysis. Emergent themes highlighted that participants were aware of diet affecting risk for the development of cancer, human papillomavirus vaccine lawsuit were less clear about its role in recurrence.

Nonetheless, their cancer diagnosis appeared to be a prompt for dietary change; predominantly to promote general health.

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Participants reported that they had not generally received professional advice about diet and were keen to know more, but were often unsure about information from other sources.

The views of our participants suggest cancer survivors would welcome guidance from health professionals.

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Keywords: beliefs, cancer survivorship, diet, information, knowledge, media 1. The mechanisms linking dietary fat intake with cancer outcomes are not well understood but are thought to be related to sex hormones such as oestrogen.

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On the other hand, intervention studies suggest that diet may influence outcomes indirectly via its role in energy balance Chlebowski et al. Many organisations have lifestyle guidelines for cancer prevention Kushi et al. Insufficient professional advice coupled with a desire for information may lead some cancer survivors to seek out information about diet themselves.

However, when searching in popular media or online, cancer survivors are likely to encounter a wealth of information, not all of which will be reliable and accurate.

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There is an abundance of media misreporting of the dietary factors that are linked to cancer risk Goldacre, that could be misleading to patients, particularly if they believe the sources to be trustworthy. However, these studies did not explore survivors' use of the media for information about diet and were conducted some time cancer and genetic changes. Determining cancer survivors' sources of information about diet and cancer will help understand why they hold particular beliefs about these factors.

Qualitative research enables us to capture cancer and genetic changes range of views and to explore why those views are held. Methods 2. This also meant we would be representing a wide range of views, applicable to the wider survivorship population as opposed to focusing on a more specific group. Interviews were chosen cancer and genetic changes focus groups as we were interested in hearing about patients' individual beliefs and experiences, rather than determining a group consensus.

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Telephone interviews also encouraged individuals to take part that cancer and genetic changes have otherwise been put cancer and genetic changes by a lack of flexibility around time e. A qualitative methodology was chosen because we were not seeking to test a hypothesis, but rather to obtain a rich source of information to better understand the rationale behind dietary beliefs and changes in this population Holliday, During this telephone call, information was given about the study with an opportunity to ask questions.

We aimed to recruit until it was felt that saturation had been reached. Interviews lasted approximately 1 hr, and were recorded and transcribed verbatim.

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A topic guide Cancer and genetic changes 1 was developed by HC, KW and RB cancer and genetic changes guide the interviews and consisted of a cancer and genetic changes of open questions covering beliefs about the relationship between diet and cancer, sources of information and changes to diet following cancer diagnosis.

This was part cancer and genetic changes a broader interview that also covered participants' views about other lifestyle factors and cancer. Interviewers were trained to have minimal verbal input and prompt only when appropriate Oppenheim, The topic guide was piloted with two participants whose data were included because no substantial changes were required.

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